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  • Title: [Selective inhibition of pyruvate dehydrogenase in the liver and heart of mice by triphosphate esters of thiochrome and tetrahydrothiamine].
    Author: Ostrovskiĭ IuM, Zabrodskaia SV, Zimatkina TI, Oparin DA.
    Journal: Biokhimiia; 1983 Jun; 48(6):928-31. PubMed ID: 6882830.
    Abstract:
    In experiments with white mice it was shown that in contrast to hydroxythiamine and other known vitamin B1 antagonists, triphosphate esters of thiochrome and tetrahydrothiamine possess a selective anticoenzyme activity with respect to the only one of the thiamine pyrophosphate-dependent enzymes, i.e. pyruvate dehydrogenase.
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