These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Comparative study of the effects of alpha-tocopherol and a synthetic antioxidant on respiration and oxidative phosphorylation in rat liver mitochondria].
    Author: Donchenko GV, Kuz'menko IV, Kovalenko VN, Kunitsa NI.
    Journal: Biokhimiia; 1983 Jun; 48(6):998-1005. PubMed ID: 6882835.
    Abstract:
    In order to decide whether vitamin E action on ubiquinone-dependent enzymatic systems of mitochondria and on ubiquinone metabolism consisting in its antioxidative function, the effects of alpha-tocopherol and the most effective synthetic antioxidant, chlorohydrate 2-ethyl-6-methyl-3-hydroxypyridine, were compared. It was shown that the contents of vitamin E and ubiquinone as well as the activities of succinate- and NADH-ubiquinone reductase, succinate- and NADH-dehydrogenases in liver mitochondria are increased and the levels of ATP, adenine nucleotides and phosphate potential in the livers of vitamin E-deficient rats are elevated 3 hours after alpha-tocopherol injection (5 micrograms per 1 g of body weight). The synthetic antioxidant injected under identical conditions at a dose of 50 micrograms per 1 g of body weight did not change the ubiquinone content or the enzymatic activities, but considerably enhanced the ATP level. The same antioxidant when injected at a dose of 105 micrograms per 1 g of body weight did not significantly affect the parameters under study but decreased the activity of succinate-ubiquinone reductase. Thus, the role of vitamin E in oxidative phosphorylation may not only consist in its antioxidant action and is largely due to the regulation of metabolism and functioning of ubiquinone.
    [Abstract] [Full Text] [Related] [New Search]