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  • Title: Ultrastructural analysis of membrane-bound polysomes in mouse "nonsecretory" myeloma (nonproducing type).
    Author: Yonezawa T, Kitani T, Yutoku M, Nishiuchi M, Hiraoka A, Tarui S.
    Journal: Blut; 1983 Sep; 47(3):147-52. PubMed ID: 6882930.
    Abstract:
    Using our electron microscopic method of polysome analysis we ascertained the numbers of membrane-bound polysomes and their constituent ribosomes in myeloma cells of J 606 (IgG3) and MOPC315 (IgA) parent cell lines and in their variants that did not produce and, accordingly, secrete either H- or L-chains. Both variants had far fewer membrane-bound polysomes than the respective parent lines. The polysome distribution curve drawn for each of these variants showed one peak at 5-6 ribosomes. In contrast to this finding, the distribution curves for the J 606 and MOPC315 parent lines gave two peaks. These observations on mouse myelomas strongly resembled those on human myelomas.
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