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  • Title: Vindesine in the treatment of malignant mesothelioma: a phase II study.
    Author: Kelsen D, Gralla R, Cheng E, Martini N.
    Journal: Cancer Treat Rep; 1983 Sep; 67(9):821-2. PubMed ID: 6883358.
    Abstract:
    Vindesine (VDS) is a new semisynthetic vinca alkaloid which has demonstrated therapeutic activity against a variety of solid tumors. A phase II trial of this agent was performed in patients with advanced malignant mesothelioma. VDS at a dose of 3 mg/m2 was given iv once weekly for 4-6 weeks and then every 2 weeks thereafter. Only one of 17 evaluable patients had a partial remission, lasting 5 months (95% confidence limits, 0%-17%). Toxic effects of VDS included leukopenia, peripheral neuropathy, and alopecia. VDS has minimal activity in malignant mesothelioma.
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