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  • Title: Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats.
    Author: El-Nahas AM, Paraskevakou H, Zoob S, Rees AJ, Evans DJ.
    Journal: Clin Sci (Lond); 1983 Oct; 65(4):399-406. PubMed ID: 6883922.
    Abstract:
    We have examined the effect of a low protein diet on the development of glomerular sclerosis and progressive renal failure after subtotal nephrectomies in rats. Two groups of male Sprague-Dawley rats were studied after five-sixths nephrectomy; group 1 were maintained on a normal diet (13.5 g day-1 kg-1 body weight) and group 2 were fed with a low protein diet (6 g day-1 kg-1 body weight). Rats maintained on a low protein diet survived for longer, and had significantly less glomerular sclerosis and significantly greater glomerular filtration rates when the experiment ended after 7 months. We conclude that dietary protein influences favourably the development of glomerular scarring and renal failure after subtotal nephrectomy in rats.
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