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  • Title: [Antidigoxin Fab-fragments in suicidal digoxin poisoning. Successful treatment of recurrent ventricular fibrillation].
    Author: Weller P, Peters U, Dickmanns HA, Hespe TH, Adam M, Allolio B, Smolarz A, Grabensee B.
    Journal: Dtsch Med Wochenschr; 1983 Sep 23; 108(38):1437-40. PubMed ID: 6884234.
    Abstract:
    A 49-year-old woman took about 12.5 mg digoxin with suicidal intent. Severe arrhythmias, including recurrent ventricular fibrillation, occurred. Sheep Fab fragments of digoxin-specific antibodies were administered i. v. at a dose of 480 mg. Serum free-digoxin concentration fell within half an hour to 0, with simultaneous rise of total digoxin from 13 micrograms/l to a maximum of 176 micrograms/l after 2 hours. At the same time there was marked improvement in the clinical condition with restoration of a stable sinus rhythm. There were no side effects to the Fab fragment administration.
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