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  • Title: Cerebral gigantism of hypothalamic origin.
    Author: Ranke MB, Bierich JR.
    Journal: Eur J Pediatr; 1983 Apr; 140(2):109-11. PubMed ID: 6884385.
    Abstract:
    In five cases of Sotos Syndrome serum somatomedin activities were measured. In two of these cases elevated levels and an increased secretion of growth hormone was observed. In one case (index case) a suspected hypothalamic tumor mass could be excluded, but hydrocephalus with increased intracranial pressure was present. The pathogenesis of gigantism in this syndrome is discussed.
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