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  • Title: Systemic, bladder wall, and bladder tumor concentration of misonidazole following intravesical administration in the rat.
    Author: Fathi MA, Fisher GJ, Pageau R, Tahan TW, Nigam VN, Brailovsky CA, Elhilali MM.
    Journal: Int J Radiat Oncol Biol Phys; 1983 Sep; 9(9):1397-400. PubMed ID: 6885552.
    Abstract:
    The hypoxic-cell radiosensitizer misonidazole was administered intravesically to normal and to bladder tumor-bearing female Fischer rats. Drug concentration was measured in the bladder wall, the tumor and in the serum using high pressure liquid chromatography at different times following administration. The data shows that misonidazole is readily adsorbed by the bladder wall and the tumor with tissue levels reaching up to 10 times those measured in the serum.
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