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  • Title: Penicillin-binding proteins in Bacteroides fragilis.
    Author: Georgopapadakou NH, Smith SA, Sykes RB.
    Journal: J Antibiot (Tokyo); 1983 Jul; 36(7):907-10. PubMed ID: 6885641.
    Abstract:
    The penicillin binding proteins (PBSs) of Bacteroides fragilis, a clinically important Gram-negative rod, were studied. Four PBPs were detected by polyacrylamide gel electrophoresis/fluorography, PBP 4 (molecular weight, 35,000) being a minor PBP. The PBP pattern was thus different from that of the Enterobacteria and Pseudomonads. Antibacterial activity of beta-lactam antibiotics was associated with binding to PBP 1 (molecular weight, 100,000), 2 (molecular weight, 86,000) and 3 (molecular weight, 68,000). Binding to PBP 2 was associated with filamentation while binding to PBP 1 resulted in cell lysis.
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