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  • Title: Hypolipidemic activity of substituted 2-pyrrolidinones in rodents.
    Author: Cocolas GH, Chapman JM, Voorstad PJ, Hall IH.
    Journal: J Pharm Sci; 1983 Jul; 72(7):812-4. PubMed ID: 6886988.
    Abstract:
    A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity at 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound at 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol levels 48% after 16 days of dosing. 4-Phenyl-5-carbethoxy-2-pyrrolidinone and 4-phenyl-3,5,5-tricarbethoxy-2-pyrrolidinone also demonstrated significant activity. Those compounds which contained a phenyl substituent were more potent than either the unsubstituted, the alkyl, or the dicarbethoxy 2-pyrrolidinone analogues.
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