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  • Title: Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome p-450.
    Author: Islam SI, Zaher FA.
    Journal: Life Sci; 1983 Sep 19; 33(12):1113-8. PubMed ID: 6888166.
    Abstract:
    The kinetics of lipid peroxide decomposition catalysed by microsomal enzymes and inhibited by SKF-525 A, hexobarbital, phenobarbital and aniline were investigated. The results indicate that the in vitro interaction of hexobarbital and SKF-525 A (type I binding compounds) with microsomal cytochrome p-450 inhibits the peroxidase activity while the in vitro interaction of aniline (type II binding compound) only slightly affect the peroxidase activity. It is suggested that LAHPO and type I binding compounds are competing for the hydrophobic binding site on cytochrome p-450, while type II binding compounds such as aniline negate electron transfer non-competitively by combining with the heme.
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