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  • Title: [Exocrine function of the pancreas under the effect of different doses of hexachlorocyclohexane].
    Author: Zakirov UB, Kadyrov UZ, Mirtursunova SZ, Guliamov TD.
    Journal: Farmakol Toksikol; 1976; 39(4):455-8. PubMed ID: 68890.
    Abstract:
    Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Of a prolonged action of relatively small doses of HCCH (1/20 and 1/50 DL50) is characteristic an initial inhibition and subsequent stimulation of the exosecretory function of the pancreas. A definite inverse relation between the amount of the introduced HCCH dose and the duration of the pancreatic inhibition period was noted.
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