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  • Title: [Echocardiographic findings of a patient with cardiac amyloidosis and left ventricular outflow obstruction].
    Author: Noma S, Akaishi M, Murayama A, Akiyama H, Ogawa S, Handa S, Nakamura Y, Sohma Y, Hosoda Y, Gotoh M.
    Journal: J Cardiogr; 1982 Mar; 12(1):267-78. PubMed ID: 6889625.
    Abstract:
    This report described 56-year-old male with cardiac amyloidosis, whose echocardiographic and hemodynamic findings suggested hypertrophic obstructive cardiomyopathy. M-mode echocardiography demonstrated asymmetric septal hypertrophy (2.1 cm/1.6 cm), systolic anterior motion of the mitral valve, and pericardial effusion. Two-dimensional echocardiography revealed marked hypertrophy of the septum and papillary muscles with characteristic fine grannular sparkling appearance of the myocardium. Bilateral heart catheterization showed normal hemodynamics except a pressure gradient of 35 mmHg within the left ventricular outflow tract. Moreover, no hemodynamic evidence of restrictive cardiomyopathy was observed. Myocardial biopsy was performed at the time of pericardiectomy, and diffuse amyloid deposits were identified between myocardial fibers. It is of particular interest that cardiac amyloidosis presented the form of ventricular hypertrophy associated with left ventricular outflow obstruction, probably due to uneven deposition of amyloid.
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