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  • Title: Regulation of plasma aldosterone by glucose-induced paradoxical hyperkalemia in the presence of suppressed renin-angiotensin system.
    Author: Radó JP.
    Journal: Endokrinologie; 1978 Apr; 72(1):51-6. PubMed ID: 688983.
    Abstract:
    In a hyperkalemic patient with stable chronic renal failure and suppression of the renin-angiotensin-aldosterone system intravenous infusion of hypertonic glucose induced a paradoxical transitory rise in serum potassium accompanied by a similar change in plasma aldosterone. The close significant correlation indicated a prominent role for serum potassium in the acute regulation of plasma aldosterone when the renin-angiotensin-aldosterone system was suppressed. However, when the renin-angiotensin-aldosterone system was stimulated by sodium depletion the glucose-induced paradoxical hyperkalemia was abolished and the governing role of potassium became less evident. The results support the concept of an equal and supplementary role of renin-angiotensin-aldosterone system and potassium in the acute regulation of aldosterone production.
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