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  • Title: Activation of plasminogen by tissue activator is increased specifically in the presence of certain soluble fibrin(ogen) fragments.
    Author: Verheijen JH, Nieuwenhuizen W, Wijngaards G.
    Journal: Thromb Res; 1982 Aug 15; 27(4):377-85. PubMed ID: 6890721.
    Abstract:
    Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer greater than D-dimer greater than Y greater than D EGTA greater than Dcate greater than X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a fibrin polymer is apparently not a prerequisite for this potentiating effect. The plasminogen activation by various urokinase preparations is not potentiated by fibrin and fibrin(ogen) fragments.
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