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  • Title: Steroid responsiveness. A predictor of the outcome of splenectomy in children with chronic immune thrombocytopenic purpura.
    Author: Weinblatt ME, Ortega JA.
    Journal: Am J Dis Child; 1982 Dec; 136(12):1064-6. PubMed ID: 6890763.
    Abstract:
    Splenectomy is curative for many children with chronic immune thrombocytopenic purpura (ITP), but not without placing them at increased risk for serious infections. To determine the reliability of a trial of corticosteroids in predicting the outcome of splenectomy, 36 children with chronic ITP were studied retrospectively. All 20 of the children with a good response to corticosteroids achieved a complete remission after splenectomy, whereas only two of 13 nonresponders exhibited a lasting benefit from surgery. Corticosteroid responsiveness was found to be a highly reliable method of correctly identifying those patients with chronic ITP who would benefit from splenectomy.
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