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  • Title: Inhibition of erythrocyte and plasma cholinesterase by 5-hydroxytryptamine.
    Author: Osman MY, Mahfouz MM, El-Habet AE, El-Sherbini H.
    Journal: Arzneimittelforschung; 1982; 32(9):1120-2. PubMed ID: 6890835.
    Abstract:
    The inhibition of human erythrocytes and plasma cholinesterase (ChE) by 5-hydroxytryptamine in vitro was studied. Constants characterising this inhibition, namely the inhibition rate for red blood cells RBCs (2.5 x 10(4) (mol/l)-1 min-1) and plasma ChE (1.08 x 10(4) (mol/l)-1 min-1) as well as the rate constant for spontaneous reactivation for RBCs (0.3 min-1) and plasma ChE (0.26 min-1) were calculated. The inhibition of RBCs and plasma ChE by 5-hydroxy-tryptamine was found to be of the competitive type.
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