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  • Title: [Influence of benzbromarone on the pharmacokinetics and pharmacodynamics of oxipurinol].
    Author: Rüffer C, Zorn G, Henkel E, Mitzkat HJ.
    Journal: Arzneimittelforschung; 1982; 32(9):1149-52. PubMed ID: 6890841.
    Abstract:
    1. When giving 100 mg allopurinol and 20 mg benzbromarone in a fixed combination we found that the oxipurinol levels differed at 0 and after 4 h from those after administration of 100 mg allopurinol; the oxipurinol clearance is increased; benzbromarone increased the glomerular filtration rate as well as the urine volume. 2. The urate serum levels are decreased under additional administration of benzbromarone, the urate clearance is increased; urate levels in serum dropped slower than under monotherapy with alloprinol and increased again within the last 12 h.
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