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  • Title: Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome.
    Author: Attanasio A, Blank B, Rager K, Gupta D.
    Journal: Endokrinologie; 1982 Oct; 80(2):129-34. PubMed ID: 6891632.
    Abstract:
    Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.
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