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  • Title: Immunoradiometric assay for human thyroglobulin and variations in thyroid pathology.
    Author: Eber M, Abecassis J, Grob JC, Ott G, Methlin G.
    Journal: Clin Chim Acta; 1980 Jul 17; 105(1):51-8. PubMed ID: 6893171.
    Abstract:
    A specific and sensitive double antibody radioimmunoassay for measuring human serum thyroglobulin (Tg) has been developed. Serum Tg levels are reported for patients with differentiated and undifferentiated thyroid carcinomas, post-treated and untreated hyperthyroidism, thyroiditis, and cold nodular goiters. We have studied results of serum Tg levels in the follow-up and care of patients who have undergone total thyroidectomy for differentiated thyroid carcinomas. Tg has no diagnostic value in the detection of thyroid cancer, but is a reliable index of metastatic growth in the follow-up of patients with differentiated carcinomas. In addition, serum Tg determination might be helpful in the aetiological diagnosis of bone or lung metastases of unknown origin.
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