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  • Title: Experimental data on the prevention of retrolental fibroplasia by D-penicillamine.
    Author: Karmazsin L, Lakatos L, Balla G, Makay A, Hatvani L.
    Journal: Acta Paediatr Acad Sci Hung; 1980; 21(2-3):131-8. PubMed ID: 6894055.
    Abstract:
    Superoxide dismutase activity of alveolar macrophages, lung, liver, retina and choroid has been studied in rats and rabbits exposed to oxygen at high concentration by itself and in combination with D-penicillamine. Prolonged hyperoxia caused an increase in superoxide dismutase activity while D-penicillamine was found to inhibit the inductive effect of oxygen. It is assumed that the antioxidative effect of D-penicillamine makes it unnecessary to augment the production of superoxide dismutase.
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