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  • Title: Chromosome replication in mouse intraspecific hybrids.
    Author: Spurná V, Nebola M, Kamenická E.
    Journal: Acta Biol Acad Sci Hung; 1980; 31(1-3):273-81. PubMed ID: 6894347.
    Abstract:
    Hybrid cells (HY SS2 and HY SS6) arising from the fusion of diploid cells of the mouse lymphosarcoma LS/BL and L cells resistant to 8-azaguanine (HGPRT-) showed slower growth and a longer generation time than the parent lines. The inter- and intrachromosomal timing and patterns of early chromosome DNA replication of parent cells was preserved in the hybrid genome and was not influenced by loss of telocentric chromosomes from LS/BL or L (HGPRT-) cells. Thus DNA chromosome replication sequences are not dependent on the presence of a complete set of chromosomes of the parent cells and do not therefore seem to be a result of interaction between chromosomes not segregated in the hybrid genome.
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