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  • Title: [Determination of bumadizone, phenylbutazone and oxyphenbutazone in human plasma by high-performance liquid chromatography (author's transl)].
    Author: Spahn H, Mutschler E.
    Journal: Arzneimittelforschung; 1981; 31(3):495-9. PubMed ID: 6894379.
    Abstract:
    HPLC methods are described to determine bumadizone, phenylbutazone and oxyphenbutazone in human plasma. The procedure for the determination of phenylbutazone and oxyphenbutazone is based on a microphase extraction and especially suitable for routine analyses because of its simplicity and rapidity. 0.5 microgram of the compounds per milliliter plasma can easily be determined; the relative standard deviations of the methods are between 0.7 and 4.4% at therapeutic plasma concentrations.
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