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  • Title: Studies on the involvement of prostaglandins in implantation in the rat.
    Author: Phillips CA, Poyser NL.
    Journal: J Reprod Fertil; 1981 May; 62(1):73-81. PubMed ID: 6894466.
    Abstract:
    Studies of prostaglandin (PG) production by uterine homogenates of rats in early pseudopregnancy and pregnancy showed that production of 6-oxo-PGF-1 alpha, PGF-2 alpha and PGE-2 peaked on Day 5 of pseudopregnancy whereas only 6-oxo-PGF-1 alpha and PGE-2 peaked on Day 5 of pregnancy, the day of implantation. 6-Oxo-PGF-1 alpha was the major product in both reproductive states. Indomethacin treatment of rats during early pregnancy caused a delay in implantation, a significant reduction in uterine weight, and a much reduced number or absence of implanted blastocysts in the uterus on Day 9. Plasma progesterone levels were also significantly lower in indomethacin-treated, pregnant rats. These findings support roles for prostaglandins in implantation, and in fetal development.
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