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  • Title: Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system.
    Author: Kumar R, Nagubandi S, Londowski JM.
    Journal: Dig Dis Sci; 1981 Mar; 26(3):242-6. PubMed ID: 6894570.
    Abstract:
    When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.
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