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  • Title: The chemotherapy of C3H mice bearing Gardner lymphosarcoma with bovine fibrinogen-methotrexate derivative.
    Author: Motycka K, Slavík K, Dyr JE, Balcarová A, Vodrázka Z.
    Journal: Neoplasma; 1981; 28(1):3-10. PubMed ID: 6895104.
    Abstract:
    Derivative of bovine fibrinogen (FBG) containing chemically bound methotrexate (MTX) has been prepared by action of ethyldimethylaminopropyl carbodiimide. The derivative retained its solubility and clotability. Intraperitoneally administered FBG-MTX derivative one day after transplantation of the ascitic Gardner lymphosarcoma prolonged distinctly the survival of C3H mice. The intravenous application of FBG-MTX derivative to mice bearing the solid form of the tumor exerted chemotherapeutic effect resulting in prolongation of survival. The local application of FBG-MTX solutions followed by injection of thrombin resulted in the formation of a fibrin clot in the tumor area which persisted at least 48 hours. Local chemotherapy of the solid tumor with fibrin clot containing MTX performed on day 1 or 3 led to significant prolongation of survival of the treated animals. Mechanism of MTX liberation and the possible application of FBG-MTX derivative in chemotherapy of tumors are discussed.
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