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  • Title: Acute effect of methamphetamine on heme oxygenase activity and on cytochrome P-450 content in the liver of female rats.
    Author: Hamasaki K, Ariyoshi T.
    Journal: J Pharmacobiodyn; 1981 May; 4(5):374-6. PubMed ID: 6895234.
    Abstract:
    After a single treatment with d-methamphetamine (philopon) at a dose of 8 mg/kg in 10 weeks old female Wistar rats, heme oxygenase activity was enhanced at 3 hr and reached it peak level at 12 hr, whereas cytochrome P-450 content showed the lowest level at 12 hr. However, activity of delta-aminolevulinic acid synthetase was not affected. Twenty-four hr later, all measured parameters returned to nearly initial levels at zero time. The pretreatment with cycloheximide blocked the increase of heme oxygenase activity in philopon-treated animals.
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