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  • Title: Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.
    Author: Krell RD, Osborn R, Falcone K, Vickery L.
    Journal: Prostaglandins; 1981 Sep; 22(3):423-32. PubMed ID: 6895417.
    Abstract:
    The activity of the SRS-A antagonist FPL 55712 against histamine, carbachol and ion-induced contraction of isolated airway smooth muscle was evaluated. FPL 55712 enhanced responses of guinea-pig trachea and parenchymal lung strips to histamine and carbachol. Enhancement was not obviously related to concentration. It is suggested that this effect may be the result of cyclo-oxygenase inhibition by FPL 55712. These observations may account for some of the anomalous findings regarding the antagonism of leukotrienes by FPL 55712 previously reported.
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