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  • Title: Disseminated sinus histiocytosis with massive lymphadenopathy: its pathologic aspects.
    Author: Buchino JJ, Byrd RP, Kmetz DR.
    Journal: Arch Pathol Lab Med; 1982 Jan; 106(1):13-6. PubMed ID: 6895583.
    Abstract:
    Sinus histiocytosis with massive lymphadenopathy (SHML) is generally regarded as a benign, self-limited, pseudolymphomatous process requiring little or no therapy. We studied a 13-year-old black boy with a ten-year clinical course of SHML that had varying, intermittent sites of extranodal involvement, including bone, submandibular gland, trachea, eye, and spinal cord. At the time of death, which was attributed to SHML, additional extranodal sites of involvement included thymus, kidney, heart, liver, and base of brain. Microscopic examination of the SHML lesions at the time of autopsy revealed varying stages of development, from proliferation to involution. This case illustrates that SHML may involve multiple organ systems, can kill, and that histologic evaluation of disease activity at one site cannot be used as an indicator of activity at another.
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