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  • Title: [In vitro development of the postimplantation embryos of laboratory rodents in human blood serum].
    Author: Popov VB, Puchkov VF, Ignat'eva TV.
    Journal: Arkh Anat Gistol Embriol; 1981 Oct; 81(11):92-6. PubMed ID: 6895691.
    Abstract:
    Rat and mouse embryos at the stage of the first somites formation (1-5 pairs) cultivated in human blood serum demonstrated its embryolethal and teratogenic effect. The embryos taken at a later stage (11-18 pairs of somites) developed normally and could be compared with the development of the rat embryos in homologous blood serum. There was no difference in the development when the embryos were cultivated either in male or female blood serum. The stage of embryogenesis 11-18 pairs of somites is recommended for in vitro experimental revealing in the human serum of embryotoxic factors induced by certain external influences.
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