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  • Title: Transition of a liquid crystalline phosphatidylcholine bilayer to the gel phase in a vesicle reduces the internal aqueous volume.
    Author: Lichtenberg D, Felgner PL, Thompson TE.
    Journal: Biochim Biophys Acta; 1982 Jan 22; 684(2):277-81. PubMed ID: 6895700.
    Abstract:
    The liquid crystalline to gel phase transition in phospholipid bilayers is associated with a marked reduction in the area per phospholipid molecule. Geometric considerations based on published data suggest that this decrease in molecular area is accompanied by a reduction in the internal aqueous volume trapped within a unilamellar bilayer vesicle. This volume reduction, which depends upon the shape of the vesicle, is shown to be between 23 and 60 percent. We have observed a 25 to 30 percent reduction in the internal aqueous volume of unilamellar vesicles about 700 A in diameter formed from dipalmitoylphosphatidylcholine using the self-quenching of 6-carboxyfluorescein trapped within this compartment.
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