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  • Title: The role of amniotic fluid phospholipids in determining fetal lung maturity.
    Author: Pappas AA, Mullins RE, Gadsden RH.
    Journal: Ann Clin Lab Sci; 1982; 12(4):304-7. PubMed ID: 6897158.
    Abstract:
    Assessment of the status of amniotic fluid phospholipids (qualitative and semi-quantitative) has become important in determining fetal lung maturity. In uncomplicated pregnancies, it has been documented that the ratio of lecithin to sphingomyelin (L/S ratio), with respect to pediatric gestational age, is a reliable predictor of maturity. In complicated pregnancies (e.g., toxemia, diabetes mellitus) the L/S ratio may result in erroneous clinical interpretation and premature intervention. The presence of phosphatidyl-glycerol (PG) in these cases has been acknowledge to be a significant factor indicative of fetal lung maturity. Thin-layer chromatography, which clearly elucidates the six phospholipids of amniotic fluid, is the method of choice.
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