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Title: [Phase separation in dipalmitoyl phosphatidylcholine bilayers induced by ionophores and binary electrolytes]. Author: Gracheva OA, Sokolova AE, Lev AA. Journal: Biofizika; 1982; 27(5):795-9. PubMed ID: 6897197. Abstract: Thermotropic behavior of unsonicated aqueous dispersion of dipalmitoyl phosphatidylcholine (DPPC) has been studied by scanning microcalorimetry and fluorescent probe method. Phase separation in the lipid bilayers was observed for systems containing ionophores (valinomycin, dinactin) and 1 : 1 electrolytes (NaCl, KCl, RbCl, CsCl). The ratio of lipid phases coexisting in the systems appeared to be dependent on the concentration of the electrolytes. Changes in the thermotropic properties of the lipid phase induced by valinomycin were observed when K+ and Rb+ ions-forming complexes with the ionophore were present in the systems. The latter phenomenon was not found for the systems containing dinactin possessing a lower ability for complex formation with the cations.[Abstract] [Full Text] [Related] [New Search]