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  • Title: A comparison of the effects of pirenzepine and atropine on gastric acid secretion, salivary secretion and pupil diameter in the rat.
    Author: Parry M, Heathcote BV.
    Journal: Life Sci; 1982 Oct 04; 31(14):1465-71. PubMed ID: 6897277.
    Abstract:
    The ability of pirenzepine and atropine, given i.v., to inhibit gastric acid and salivary secretion and increase pupil diameter has been assessed in the rat. Pirenzepine had a similar potency against acid secretion, ED 50 0.71 (0.41 to 1.1) mg.kg-1, and salivary secretion, ED 50 (0.43 to .59) mg.kg-1, whilst its potency was less in the eye, ED 50 1.8 (1.6 to 2.1) mg.kg-1. Atropine however, was more potent in reducing salivary secretion, ED 50 0.012 (0.010 to 0.016) mg.kg-1 and increasing pupil diameter, ED 50 0.028 (0.025 to 0.031) mg.kg-1 than in inhibiting gastric acid secretion, ED 50 0.056 (0.037 to 0.083) mg.kg-1. Therefore, that quantity of pirenzepine which inhibits gastric acid secretion by 50% will have only a slight effect on the eye and will inhibit salivary secretion by a similar magnitude. In contrast, the amount of atropine required to inhibit acid secretion by 50% will significantly increase pupil diameter and abolish salivary secretion.
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