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  • Title: Does pirenzepine distinguish between 'subtypes' of muscarinic receptors?
    Author: Szelenyi I.
    Journal: Br J Pharmacol; 1982 Dec; 77(4):567-9. PubMed ID: 6897522.
    Abstract:
    Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea-pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol-evoked changes in all three organs in a dose-dependent manner. The slopes of the Schild-plots confirmed the competitive nature of the antagonism by pirenzepine. The estimated pA2-values were very similar. Based on these data, it might be concluded that pirenzepine is an anticholinoceptor compound without specific affinity for gastric muscarinic receptors.
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