These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Levels of plasma 1,25-dihydroxyvitamin D and parameters of phospho-calcium metabolism in children with non-dialyzed chronic renal failure].
    Author: Loras B, Parchoux B, Durr F.
    Journal: Arch Fr Pediatr; 1982 Dec; 39 Suppl 2():755-60. PubMed ID: 6897703.
    Abstract:
    1,25-diOH vitamin D, 25-OH vitamin D, parathyroid hormone, calcium and phosphorus were measured in the blood of 34 children and correlated. These children, 3 months to 17 years old, had chronic renal insufficiency of varying intensity. 15 of them were treated with vitamin D. We found a negative correlation between the 1,25-diOHD levels and the reduction of the clearance of inuline, serum creatinine and uremia. This suggests a defect in 1,25-diOHD synthesis appearing when the glomerular filtration rate is decreased by about 50%, except in the case of tubulopathies, where it appears earlier. In these children, the 1,25-diOHD levels correlated with calcemia, but not with phosphoremia. The high levels of PTH were related with the lowest levels of 1,25-diOHD. The regulation of calcemia is thus basically controlled by the renal possibilities. There was a positive correlation between 1,25-diOHD and 25OHD levels when GFR was lower than 0.6 ml/sec./1,73 m2, indicating a dependence of 1,25-diOHD levels or its substrate in severe chronic renal failure.
    [Abstract] [Full Text] [Related] [New Search]