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  • Title: The rabbit properdin system: I. Identification of a new factor and purification of rabbit properdin.
    Author: Naff GB, Hedrick SW, Ratnoff WD, Novak MA, Smith MC, Steiner C, Todd EW.
    Journal: J Immunol; 1980 Jun; 124(6):2625-31. PubMed ID: 6900053.
    Abstract:
    Pure preparations of rabbit properdin were obtained from rabbit serum by ion-exchange chromatography. These preparations functioned as properdin when they were measured with the zymosan assay or with a serum reagent selectively depleted of properdin by a specific immunoabsorbent. Properdin in these preparations was in its activated state. A new serum factor was required to measure properdin activity when purified preparations of rabbit properdin were tested with the zymosan assay. This factor was designated as ZBP, or zymosan-binding protein. ZBP appeared to be distinct from known components of the alternative complement pathway and the classical complement system, and it did not appear to be an immunoglobulin.
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