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  • Title: Do fat emulsions protect against infusion thrombophlebitis? An experimental study.
    Author: Hessov I, Bojsen-Møller M, Melsen F.
    Journal: Intensive Care Med; 1978 Jul; 4(3):155-7. PubMed ID: 690324.
    Abstract:
    The clinical experience that a fat emulsion (Intralipid) protects the vein against infusion thrombophlebitis caused by an amino acid solution (Aminosol) was controlled by an experimental method based on a quantitative histological analysis of the inflammatory changes observed in the veins of rabbit ears after infusions. In a controlled blind study, sequential analysis failed to reveal any difference in the histological changes which developed after infusion of Aminosol alone and Aminosol plus Intralipid. In a second series of experiments in which Intralipid was compared with 0.9% NaCl it was demonstrated that the fat emulsion alone gave rise to considerable inflammatory changes in the veins.
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