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  • Title: Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.
    Author: Ramachander G, Bapatla KR, Emele JF.
    Journal: J Pharm Sci; 1978 Sep; 67(9):1326-7. PubMed ID: 690847.
    Abstract:
    Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan. Upon oral administration of this drug, the plasma half-life of dextrorphan, a major biotransformation product formed by O-demethylation, was 40 min in the female rat and 18.5 min in the male.
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