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  • Title: Bf polymorphism and its relationship with HLA antigens in a sample of the Spanish Population: high BfF1 frequencies.
    Author: Rodriguez-Córdoba S, Bootello A, Arnaiz-Villena A.
    Journal: Tissue Antigens; 1981 Feb; 17(2):231-7. PubMed ID: 6908966.
    Abstract:
    Bf allele frequencies were studied in a sample of the normal Spanish population and in family haplotypes. BfF1 shows a frequency higher than in other Caucasoid populations and closer to that found in Negroids. Basques show an even higher BfF1 frequency BfF1 is in strong linkage disequilibrium with B18. HLA-Bw44 is found to be the B12 split in linkage disequilibrium with BfF and Bw50-BfS1 association is confirmed. DR3--BfF1 are not in linkage disequilibrium in the normal Spanish population, in contrast to DR3--BfF1 in linkage found in a diabetic Spanish population. Results are discussed on the bases of the paleo-North African Iberian population origins and of the use of Bf to define B12 and Bw21 splits.
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