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  • Title: [Interrelation of the blood kallikrein-kinin and anticoagulation systems in experimental myocardial infarct].
    Author: Ponomareva AG, Churakov IuA, Trapezontseva RA, Stepanenko SB.
    Journal: Kardiologiia; 1981 Jun; 21(6):89-93. PubMed ID: 6911343.
    Abstract:
    The activity of the kallikrein-kinin and anticoagulation blood systems was studied in dogs with experimental myocardial infarction. Changes were revealed in the kallikrein-kinin system which create conditions for uncontrolled production of kinins in the first 24 hours of the disease. A direct correlation was detected between the activity of kallikrein and plasmin in the first three days of experimental myocardial infarction, which the authors claim to be a pathophysiological reaction of the body because it is conductive to the uncontrolled production of kinins. It is also noted that in this pathological process the depression of the anticoagulation system in the first two days is mainly due to reduced activity of nonenzymatic fibrinolysis, while, beginning with the third day, it is caused by reduced activity of enzymatic fibrinolysis, increased antiplasmin activity in particular.
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