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  • Title: Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor.
    Author: Gauthier F, Fryksmark U, Ohlsson K, Bieth JG.
    Journal: Biochim Biophys Acta; 1982 Jan 18; 700(2):178-83. PubMed ID: 6915782.
    Abstract:
    The rate constant for the association between human leukocyte elastase (EC 3.4.21.11) and human bronchial inhibitor has been determined by competition experiments with alpha 1-proteinase inhibitor. This constant (1.1.10(7) M(-1) . s(-1)) is 6-times lower than that for the association of leukocyte elastase and alpha 1-proteinase inhibitor. The latter inhibitor is able to dissociate the leukocyte elastase-bronchial inhibitor complex with a rate constant 1.3.10(-4) s-1. The equilibrium dissociation constant Ki of the complex is 1.2.10(-11) M. The physiopathological significance of these constants is discussed.
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