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  • Title: Evaluation of treatment for pancreatic exocrine insufficiency in dogs with ligated pancreatic ducts.
    Author: Pidgeon G, Strombeck DR.
    Journal: Am J Vet Res; 1982 Mar; 43(3):461-4. PubMed ID: 6918196.
    Abstract:
    Clinical evaluations and measurements of maldigestion and malabsorption were made in dogs before and after ligation of pancreatic ducts. Fecal wet and dry weights were 300% greater after duct ligation. Fecal fat excretion of dietary intake increased from 9% to 84%. An indirect test of pancreatic function revealed a disappearance of intestinal chymotrypsin activity. All values tested improved during replacement with 5 ml of enzyme powder/day. Little additional improvement was observed after doubling or quadrupling this dose. Little or no additional improvement was seen with the following additions to enzymes: 30-minute preincubation of enzymes with food, antacids, cimetidine (except high dose), neomycin, or bile acids. Enzymes in uncoated tablets were less effective, unless the tablets were crushed.
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