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  • Title: [Risks and prognosis for success of a pregnancy following replacement of a heart valve (author's transl)].
    Author: Rein J, von der Emde J, Fritsche-Paulus U.
    Journal: Geburtshilfe Frauenheilkd; 1982 Jun; 42(6):444-9. PubMed ID: 6921125.
    Abstract:
    After replacement of a heart valve a pregnancy is possible in the complaint categories I and II. Treatment with anti-coagulation is necessary for plastic heart valves. To avoid teratogenic effects the early pregnancy is best managed with heparin although stillbirth and early intra-uterine death are more common than with Marcumar. A treatment with heparin 10,000 units subcutaneously twice throughout all of the pregnancy is recommended. According to the literature 2/3 of the pregnancy with anti-coagulation result in the normal delivery of a healthy infant. Of 202 women in the reproductive age group with artificial heart valves, 150 were followed by a questionnaire. 25 women desired children. 10 women had pregnancies. 1 had two pregnancies, 1 had three pregnancies, 3 healthy infants were born.
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