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  • Title: Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate.
    Author: Iwasawa H, Kondo S, Ikeda D, Takeuchi T, Umezawa H.
    Journal: J Antibiot (Tokyo); 1982 Dec; 35(12):1665-9. PubMed ID: 6926749.
    Abstract:
    The method for chemical modification of spergualin with retention of the configuration at the C-11 has been achieved by the use of tetrahydropyranyl group for protection of the 11-hydroxyl group. (-)-15-Deoxyspergualin (2), which shows about eight times stronger inhibition against mouse leukemia L-1210 than the natural (-)-spergualin(1), and (-)-spergualin-15-phosphate(3) possessing a good antitumor activity have been synthesized starting from 1.
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