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  • Title: Chromosome fragility in New Zealand black mice: effect of ultraviolet and gamma radiations on fetal fibroblasts in vitro.
    Author: Reddy AL, Fialkow PJ.
    Journal: J Natl Cancer Inst; 1980 Apr; 64(4):939-41. PubMed ID: 6929005.
    Abstract:
    The sensitivity of fibroblasts cultured from New Zealand Black (NZB) and BALB/c mouse fetuses to UV and gamma radiations was tested with two methods: 1) colony-forming ability and 2) chromosome abnormalities. When compared with BALB/c cells, NZB cells had reduced colony-forming ability and increased chromosome abnormalities after UV irradiation. However, no differences were seen in colony formation or frequency of chromosome abnormalities between NZB and BALB/c cells after exposure to gamma radiation. This apparent UV specificity strengthens the suggestion that NZB mice might be used as a model to study the relationship between chromosome abnormalities and cancer in human syndromes such as xeroderma pigmentosum, which is characterized by chromosome instability.
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