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  • Title: Limited DNase I nicking as a probe of gene conformation.
    Author: Zasloff M, Camerini-Otero RD.
    Journal: Proc Natl Acad Sci U S A; 1980 Apr; 77(4):1907-11. PubMed ID: 6929527.
    Abstract:
    We have extended the use of pancreatic DNase I as a probe of chromatin structure by exploring the accessibility of an active gene to the introduction of the first single-stranded nick. We show by a target analysis that the beta-globin gene is about 25-fold more sensitive to single-site nicking than is an average sequence in the chicken erythrocyte nucleus or the nontranscribed albumin gene. The sites of initial DNase I nicking are shown to cluster within the transcribed sequence of the beta-globin gene.
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