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  • Title: [Age and features of the suppressor activity of antigen primed spleen cells of CBA strain mice and regulation of the immune response in old age].
    Author: Andrianova LF.
    Journal: Ontogenez; 1978; 9(4):411-6. PubMed ID: 692981.
    Abstract:
    A study of primary immunological response to the ram erythrocytes and response of primed CBA mice of different age has shown a sharp fall of the primary immunological response in senility. The young animals responded to the priming by the decrease of formation of direct antibody-forming cells in the spleen what is connected with the activation of suppressor cells. The response of primed animals increased with the age and attained in old mice the values markedly exceeding that of primary immunological response. In the system of syngeneic adoptive transfer of the spleen cells from the primed mice of different age, the response of recipients of young animal's cells was lower that of recipients of old animal's cells. The data obtained suggest the devrease of the suppressor activity of the primed spleen cells with the age.
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