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  • Title: Screening for malignant hyperthermia susceptibility.
    Author: Anderson IL, Rawstron RE, Dunlop DJ.
    Journal: N Z Med J; 1980 Jun 11; 91(661):417-9. PubMed ID: 6930029.
    Abstract:
    In vitro pharmacological testing of isolated muscle strips surgically removed under general anaesthesia from 10 members of a known MH family enabled identification of three MH positive individuals. Diagnosis of MH susceptibility was based on increased sensitivity to low concentrations of caffeine and the presence of halothane-induced contractures in MH susceptible muscle. Dantrolene sodium 15 mg/l completely prevented halothane-induced contractures in two muscle strips from one of the MH positive cases. The successful anaesthetic management of known MH patients is described, as is the successful management of a hyperthermic episode during recovery in one of the MH positive cases.
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