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  • Title: Salivary lithium concentration--a tool for monitoring psychiatric patients.
    Author: Ben-Aryeh H, Naon H, Szargel R, Gutman D, Hefetz A.
    Journal: Oral Surg Oral Med Oral Pathol; 1980 Aug; 50(2):127-9. PubMed ID: 6930611.
    Abstract:
    Salivary and serum lithium concentrations were measured simultaneously in 118 manic-depressive patients. Lithium concentration in saliva was 2.24 +/- 0.35 times higher than in serum. An equation to calculate serum lithium concentration from salivary measurements was derived: Li serum = 0.36 Li saliva + 0.13. Psychotropic drugs had no effect on the salivary:serum ratio. Eighteen patients were followed for several weeks. A significant correlation coefficient between salivary and serum lithium concentrations was found in thirteen of the eighteen patients studied.
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